Home Anti-Oxidant Biological processes Similar Molecule Links

Vitamin C as an Anti-Oxidant and Free Radical Inhibitor

It has been demonstrated that when human fibroblasts are exposed to reactive oxygen species (free radicals), less collagen is produced. Wrinkles and skin sagging are commonly believed to occur as a result of the cross-linking of elastin and collagen. Free radicals are thought to be responsible for this cross-linking. Excessive exposure to UV radiation can give rise to free radicals. UV radiation penetrates deep into the skin, generating free radicals and other reactive agents which, in turn, attack and damage the lipids that make up the dermal layers beneath the surface of the skin. The body neutralizes these free radicals with vitamin C. In vivo experiments have demonstrated that a combination of vitamin E and vitamin C is a powerful inhibitor of lipid peroxidation.

Topical vitamin C is also capable of controlling the inflammation resulting from ultraviolet exposure which eventually leads to wrinkling and skin cancer. Experiments show that topically applied vitamin C is absorbed into the dermis in levels high enough to protect the skin from UV radiation damage as measured by erythema and sunburn formation.

Back to Top



Vitamin C is involved in over 300 biological processes in the body.

COLLAGEN - Vitamin C is necessary for the manufacture of collagen, the protein which forms the basis of connective tissue. The most abundant tissue in the body, connective tissue acts as a cementing substance between cells. It helps support and protect blood vessels, bones, joints, organs and muscles and forms a sizeable proportion of skin, tendons, the cornea of the eye, ligaments, cartilage, teeth and bone. Collagen forms a protective barrier and promotes healing of wounds, fractures and bruises.

ANTIOXIDANT - Vitamin C is the body's most powerful water soluble antioxidant and plays a vital role in protecting the body against oxidative damage. It neutralizes potentially harmful reactions in the watery parts of the body such as the blood and the fluid inside and surrounding cells. It helps protect LDL cholesterol against free radical damage. This antioxidant action helps to protect the health of the heart and an array of other body tissues.

HORMONES -
Vitamin C is important in the synthesis of hormones by the adrenal glands.

CARDIOVASCULAR SYSTEM - Vitamin C plays a role in cholesterol production in the liver and in the conversion of cholesterol to bile acids for excretion. It supports normal total blood cholesterol and LDL cholesterol and raises beneficial HDL cholesterol. Vitamin C also supports normal circulation, therefore supporting the health of the heart. Vitamin C also helps control healthy blood pressure.

NERVOUS SYSTEM - Vitamin C plays a role in the conversion of tryptophan to serotonin, a neurotransmitter with many vital functions.
Absorption: Body tissue stores of vitamin C are small and easily saturated, with any excess excreted in two to three hours.

Therapeutic effects: Vitamin C has a number of health effects

CARDIOVASCULAR SYSTEM - Vitamin C may protect the heart by preventing the oxidation of artery clogging LDL cholesterol. Studies have shown that high vitamin C intake is linked to heart health. Vitamin C may also be of benefit in the support of normal high blood pressure and circulation.

LUNGS - There is some evidence that vitamin C may be of benefit in maintaining the health of the respiratory system. This effect may be due to the antioxidant effect of vitamin C on oxidizing agents. Vitamin C may also improve lung and white blood cell function and decrease respiratory stress.

IMMUNITY - Vitamin C boosts immunity by increasing the production of B and T cells and other white blood cells, including those with a critical role in natural defenses. It also increases interferon levels and antibody responses and has antiviral and antibacterial effects. These immune stimulating effects lead to improved resistance against infections. Vitamin C may reduce the duration of colds and the severity of cold symptoms such as sneezing, coughing and sniffling by reducing blood levels of histamine which can trigger tissue inflammation and runny noses: though the research is contradictory and inconclusive. It may also protect the immune cells and surrounding tissue from oxidative reactions that occur when cells fight bacteria.

CATARACTS - Many studies show that vitamin C may protect the health of the eye, possibly by reducing ultra violet damage. Vitamin C is highly concentrated in the lenses of normal eyes which may contain 60 times the amount of vitamin C as the blood, while stressed lenses have levels that are much lower. Vitamin C may act to protect the lens from oxidative damage and protect enzymes within the lens that remove oxidation damaged proteins.

DIABETES - Increasing vitamin C intake in diabetics may support circulation, especially micro-circulation.

OTHER BENEFITS - Vitamin C may also protect the skin from sun damage, improve response to stress including an improvement in athletic performance due to the effects on adrenal hormones.

Interactions: Vitamin C helps in the body's absorption of iron by helping convert dietary iron to a soluble form. It is also involved in the conversion of folic acid to its active state. Vitamin C deficiency may lead to increased excretion of vitamin B6 and vitamin B6 deficiency leads to low levels of vitamin C as can a deficiency of vitamin A. Vitamin C protects against the toxic effects of cadmium, copper, vanadium, cobalt, mercury and selenium. Large doses of vitamin C may lower vitamin B12, copper and selenium blood levels. Calcium and manganese supplements may decrease vitamin C excretion and vitamin C supplements may increase manganese absorption.

Exposure to cigarette smoke or air pollutants such as ozone and carbon monoxide may deplete vitamin C in the lungs.

Large doses of vitamin C may interfere with contraceptive pill absorption and reduce its effectiveness.

Aspirin, alcohol antibiotics and steroids may increase vitamin C requirements.

Vitamin C may diminish the response to some antidepressants, and the anticoagulant drug warfarin.

Back to Top



SIMILAR MOLECULE

Back to Top


LINKS

Ohio State University Extension Fact Sheet
The Antioxidant Vitamin - Vitamin C -
Everything you need to know about Vitamin C
Vitamin C and your Health
A GOOD Page

Back to Top