|Nomenclature and Structure|Deficiencies|Works Cited|
Functions:
Tetrahydrofolate (THF) activities:
- main function is to carry and transfer various forms of carbon units during biosynthetic reactions. One methyl units include formyl, methyl, methylene etc...
- necessary for production of nucleic acids such as DNA and RNA
- helps produces energy
- helps strengthen the body's immune system
- helps deal with severe depression
- assist in the regulation of nerve cells in fetuses.
- help prevent spina bifida
- reduce and or prevent immature births
Reactions:
- single carbon transfer reactions( methyl chain transfers)
- biosynthesis of purines
- histidine degradation
- hydroxylation of proline in order to form collagen
- helps prevent DNA damage and chromosomes breakage by attaching methyl groups to sections of the DNA
- work with t-RNA to transport certain amino acids to proper location for forming protein molecules
- regenerate limiting amino acids, methionine by recycling toxic homocysteine bacl to methionine
- dihydrofolate reductase (DHFR) acts as gene encoders to enhance DNA synthesis and promote cell division
- found to be involved in metabolism of long chain fatty acids and phospholipids to make neurotransmitters
- necessary for formation of brain, spinal cord, and nerve cells in embryo and maintain them in adult
- required for red blood cell formation
- protects against cervical cancer ( proven in 1970s)
- beneficial in treatment of atherosclerosis
Sources:
- green leafy vegetables( it was discovered in 4 tons of spinach)
- fortified cereals
- berries
- milk
- beef liver
- beans
- orange juice
- rice
- eggs
