FUNCTION
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Vitamin B6 is involved in more bodily functions than any other nutrient. It affects both physical and mental processes. Vitamin B6 is necessary in the metabolization of carbohydrates, fats, and proteins. B6 is needed to convert new amino acids to carbohydrates or fats for storage or energy. B6 helps develop hormones, neurotransmitters like serotonin, hemoglobin in red blood cells, over 60 enzymes, and other protein-related compounds. It is necessary to produce prostaglandins which are involved in blood pressure regulation, muscle contraction and heart function. Sufficient levels of B6 are needed to form and maintain the nervous system and to regulate mental processes and our mood.
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SOME
BIOCHEMICAL REACTIONS B6 PARTICIPATES IN
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1. Coenzyme for transmerases Transmerases work in protein metabolism transferring ammonia molecules from amino acid to amino acid. |
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2. Metabolizing essential fatty acids ( linoleic and linolenic acids) | |
Prostaglandins are made from essential fatty acids. B6 is required to convert linoleic acid into prostaglandin E1. A deficiency in E1 is related to schizophrenia, hyperactivity, heart disease, and cancer. | |
3. Cofactor for lysyl oxidase (needed to strengthen connective tissue in our body) | |
Long protein fibers (collagen, elastin) provide structural support for various tissues in our body. These fibers which lie side by side must be joined together. Lysyl oxidase causes certain amino acids on one fiber to bond with amino acids on the adjacent fiber. B6 helps lysyl oxidase to weave together the protein fibers.
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4. Metabolizing amino acid tryptophan to serotonin | |
Serotonin is a neurotransmitter (chemical messenger). When there is a deficiency of serotonin in your body it can cause depression, hyperactivity, and other psychiatric problems. | |
5. Cofactor for the enzyme that converts glutamic acid into the neurotransmitter GABA | |
INHIBITORS
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Hydrazines and hydrazides are inhibitors to B6. They both contain a pair of nitrogen molecules bound to each other and are structurally similar to pyridoxine. B6 is unable to bond and activate its enzyme because hydrazines and hydrazides will bond to the active site.
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